Modification of purple sweet potato starch (Ipomoea batatas L. Poir) with pragelatination and acetylation methods as disintegrant of paracetamol tablets

Background: Starch of sweet potatoes is one the ingredients that has many benefits, including in pharmaceutical field, especially as a excipient formulations. But it poor flow properties. Objective: The objective study to isolate, characterise, modify and formulate starch Purple (I. batatas L.Poir) into tablet dosage forms. Method: purple potato obtained from isolation, then modified improve its Modifications made were by pregelatination acetylation. after obtaining meets standards pharmacopoeia, used disintegrant formulation paracetamol tablets with concentration 15%. Result: physicochemical characteristics isolated are considered meet requirements excipients required Handbook Pharmaceutical Excipients sixth edition United States Pharmacopeia 32nd edition. Conclusion: potential an alternative for formulation, but amount needs be reduced so not produce brittle tablets.